The Turnover of Nuclear DNA-like RNA in HeLa Cells

The subcellular distribution of various types of RNA in HeLa cells is described. In addition, the relative rate of synthesis of the major classes of nuclear RNA has been determined. From these experiments it can be deduced that the heterogeneous nuclear RNA fraction is rapidly synthesized and degrad...

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Published inThe Journal of cell biology Vol. 39; no. 1; pp. 112 - 118
Main Authors Soeiro, R., Vaughan, M. H., Warner, J. R., Darnell, J. E.
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 01.10.1968
The Rockefeller University Press
Subjects
Animal cells
Base composition
Carbon Isotopes
Cell nucleus
Cell Nucleus - metabolism
DNA, Neoplasm - metabolism
HeLa cells
HeLa Cells - metabolism
Humans
Messenger RNA
Molecules
Nuclear RNA
Phosphorus Isotopes
Ribosomal RNA
Ribosomes
RNA
RNA, Neoplasm - biosynthesis
RNA, Neoplasm - metabolism
Uridine - metabolism
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Summary:The subcellular distribution of various types of RNA in HeLa cells is described. In addition, the relative rate of synthesis of the major classes of nuclear RNA has been determined. From these experiments it can be deduced that the heterogeneous nuclear RNA fraction is rapidly synthesized and degraded within the cell nucleus.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Dr. Vaughan's present address is the Department of Biochemistry and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.39.1.112