PROTECTION AGAINST YERSINIA INFECTION INDUCED BY NON-VIRULENCE-PLASMID-ENCODED ANTIGENS

• Published in: Journal of medical microbiology Vol. 20; no. 2; pp. 225 - 231
• Main Authors: Simonet, M, Berche, P, Mazigh, D, Veron, M
• Format: Journal Article
• Language: English
• Published: Reading Soc General Microbiol 01.10.1985; Society for General Microbiology
• Subjects: Animals; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antigens, Bacterial - genetics; Antigens, Bacterial - immunology; Biological and medical sciences; Female; Immunity, Active; Immunization; Listeriosis - immunology; Listeriosis - microbiology; Medical sciences; Mice; Mice, Inbred ICR; Pharmacology. Drug treatments; Plague - immunology; Plague - microbiology; Plasmids; Spleen - microbiology; Virulence; Yersinia - genetics; Yersinia - growth & development; Yersinia - immunology; Yersinia - pathogenicity; Yersinia enterocolitica - growth & development; Yersinia enterocolitica - immunology; Yersinia Infections - immunology; Yersinia Infections - microbiology; Yersinia pestis - growth & development; Yersinia pestis - immunology; Yersinia pseudotuberculosis Infections - immunology; Yersinia pseudotuberculosis Infections - microbiology; Infection; Prevention; Yersinieae; Yersinia; Bacteriosis; Bacteria; Enterobacteriaceae
• ISSN: 0022-2615; 1473-5644
• DOI: 10.1099/00222615-20-2-225

Laboratoire de Microbiologie, Faculté de Médecine Necker-Enfants Malades, 75730 Paris Cedex 15 et * Unité d'Ecologie Bactérienne, Centre National des Yersinia, Institut Pasteur, 75724 Paris Cedex 15, France Received November 13, 1984 Accepted January 7, 1985 Specific immunity against Yersinia was induced by plasmid-encoded antigens not associated with virulence. Mice were immunised with viable bacteria from a virulence-plasmid-cured strain of Y. pseudotuberculosis . This antigenic stimulation generated specific protection against virulence-plasmid-harbouring strains of Y. pseudotuberculosis and Y. pestis , demonstrating that protection can be generated by organisms lacking plasmid-encoded virulence antigens.