Mitochondrial dysfunction is the cause of one of the earliest changes seen on magnetic resonance imaging in Charcot neuroarthopathy – Oedema of the small muscles in the foot

The hypothesis laid out in this thesis states that the early changes seen on an MR imaging in those with early Charcot neuroarthopathy may be due to mitochondrial dysfunction. In a Charcot foot, there is movement between bones. In an attempt to prevent this movement, the small muscles of the foot co...

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Published inMedical hypotheses Vol. 134; p. 109439
Main Authors Lymbouris, Margarita, Gooday, Catherine, Dhatariya, Ketan K.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.01.2020
Subjects
Charcot neuroarthropathy
Mitochondria
Muscle oedema
Charcot neuroarthropathy
Mitochondria
Muscle oedema
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Summary:The hypothesis laid out in this thesis states that the early changes seen on an MR imaging in those with early Charcot neuroarthopathy may be due to mitochondrial dysfunction. In a Charcot foot, there is movement between bones. In an attempt to prevent this movement, the small muscles of the foot contract continuously when the foot is weight bearing. This contraction takes energy in the form of ATP. However, the reduction of glucose transport into the muscle cells due to insulin resistance / insufficiency, leads to reduction in the ATP producing capacity of the mitochondria. The ATP depletion affects the cell membrane gradient leading to mitochondrial and cellular swelling. These early cellular changes could then be picked up with MR imaging as muscle oedema.
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ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2019.109439