G-CSF, the guardian of granulopoiesis

A considerable amount of continuous proliferation and differentiation is required to produce daily a billion new neutrophils in an adult human. Of the few cytokines and factors known to control neutrophil production, G-CSF is the guardian of granulopoiesis. G-CSF/CSF3R signaling involves the recruit...

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Bibliographic Details
Published inSeminars in immunology Vol. 54; p. 101515
Main Authors Mehta, Hrishikesh M., Corey, Seth J.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2021
Subjects
CSF3R
G-CSF
G-CSFR
GCSF
Granulocytes
Granulopoiesis
MDSC
Neutrophils
G-CSFR
CSF3R
MDSC
Granulocytes
Neutrophils
G-CSF
GCSF
Granulopoiesis
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Summary:A considerable amount of continuous proliferation and differentiation is required to produce daily a billion new neutrophils in an adult human. Of the few cytokines and factors known to control neutrophil production, G-CSF is the guardian of granulopoiesis. G-CSF/CSF3R signaling involves the recruitment of non-receptor protein tyrosine kinases and their dependent signaling pathways of serine/threonine kinases, tyrosine phosphatases, and lipid second messengers. These pathways converge to activate the families of STAT and C/EBP transcription factors. CSF3R mutations are associated with human disorders of neutrophil production, including severe congenital neutropenia, neutrophilia, and myeloid malignancies. More than three decades after their identification, cloning, and characterization of G-CSF and G-CSF receptor, fundamental questions remain about their physiology.
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ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2021.101515