Subchronic co-exposure to particulate matter and fructose-rich-diet induces insulin resistance in male Sprague Dawley rats

• Published in: Environmental toxicology and pharmacology Vol. 100; p. 104115
• Main Authors: Jiménez-Chávez, Arturo, Morales-Rubio, Russell, Sánchez-Gasca, Eliu, Rivera-Rosas, Mónica, Uribe-Ramírez, Marisela, Amador-Muñoz, Omar, Martínez-Domínguez, Y. Margarita, Rosas-Pérez, Irma, Choy, Elizabeth H., Herman, David A., Kleinman, Michael T., De Vizcaya-Ruiz, Andrea
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2023
• Subjects: Fructose rich diet; Hyperinsulinemia; Insulin resistance; Insulin/AKT pathway; Particulate matter; Hyperinsulinemia; Insulin resistance; Insulin/AKT pathway; Fructose rich diet; Particulate matter
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2023.104115

Insulin resistance (IR) and metabolic disorders are non-pulmonary adverse effects induced by fine particulate matter (PM2.5) exposure. The worldwide pandemic of high fructose sweeteners and fat rich modern diets, also contribute to IR development. We investigated some of the underlying effects of IR, altered biochemical insulin action and Insulin/AKT pathway biomarkers. Male Sprague Dawley rats were subchronically exposed to filtered air, PM2.5, a fructose rich diet (FRD), or PM2.5 + FRD. Exposure to PM2.5 or FRD alone did not induce metabolic changes. However, PM2.5 + FRD induced leptin release, systemic hyperinsulinemia, and Insulin/AKT dysregulation in insulin-sensitive tissues preceded by altered AT1R levels. Histological damage and increased HOMA-IR were also observed from PM2.5 + FRD co-exposure. Our results indicate that the concomitant exposure to a ubiquitous environmental pollutant, such as PM2.5, and a metabolic disease risk factor, a FRD, can contribute to the metabolic disorder pandemic occurring in highly polluted locations. [Display omitted] •PM2.5 and FRD co-exposure disrupts Insulin/AKT pathway in insulin sensitive tissues.•Leptin, fasting insulin and HOMA-IR increase after PM2.5 and FRD co-exposure.•PM2.5 and FRD co-exposure generates a systemic insulin resistance.