Performance on a Visual Sustained Attention and Discrimination Task is Associated with Urinary Excretion of Norepineprhine Metabolite in Children with Attention-Deficit/Hyperactivity Disorder (AD/HD)

• Published in: Clinical neuropsychologist Vol. 20; no. 1; pp. 133 - 144
• Main Authors: Llorente, Antolin M., Voigt, Robert G., Jensen, Craig L., Berretta, Marcia C., Kennard Fraley, J., Heird, William C.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.02.2006
• Subjects: Attention; Attention Deficit Disorder with Hyperactivity - diagnosis; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention Deficit Disorder with Hyperactivity - urine; Central Nervous System Stimulants - therapeutic use; Child; Cognition Disorders - diagnosis; Cognition Disorders - epidemiology; Discrimination (Psychology); Female; Humans; Male; Methylphenidate - therapeutic use; Neuropsychological Tests; Norepinephrine - urine; Severity of Illness Index; Visual Perception
• ISSN: 1385-4046; 1744-4144
• DOI: 10.1080/13854040490888495

The degree of association between performance on a sustained attention task requiring visual discrimination and urinary excretion of catecholamine metabolites was examined in a cohort of 6- to 12-year-old children (n = 31) strictly selected and diagnosed with attention-deficit/hyperactivity disorder (AD/HD) according to DSM-IV and other strict criteria. Sustained visual attention and discrimination were measured using the Test of Variables of Attention (T.O.V.A.). Urinary excretion of dopamine (DA) and norepinephrine (NE) metabolites was measured by reversed high-pressure liquid chromatography (HPLC). Pearson product-moment correlations were used to investigate the relationship between T.O.V.A. errors of omission (OMM), errors of commission (COM), response time (RT), and response time variability (RTV) and catecholamine metabolites of DA and NE. All T.O.V.A. indexes under investigation were significantly correlated with urinary excretion of NE metabolites, but correlations were low-to-moderate in magnitude (.37-.50). In contrast, there were no statistically significant correlations between T.O.V.A. indices and DA metabolites. These findings and their concordance with past research in human adults and animals, as well as theoretical issues associated with the present results, are discussed.