Mapping quantitative trait loci using linkage disequilibrium: marker- versus trait-based methods

• Published in: Behavior genetics Vol. 35; no. 2; pp. 219 - 228
• Main Authors: Tenesa, Albert, Visscher, Peter M, Carothers, Andrew D, Knott, Sara A
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.03.2005
• Subjects: Humans; Linkage Disequilibrium; Models, Genetic; Quantitative Trait Loci

Two approaches for mapping quantitative trait loci (QTL) using linkage disequilibrium at the population level were investigated. In the trait-based (TB) approach, the frequencies of marker alleles (or genotypes) are compared in individuals selected from the two tails of the trait distribution. The T...