Mapping quantitative trait loci using linkage disequilibrium: marker- versus trait-based methods

• Published in: Behavior genetics Vol. 35; no. 2; pp. 219 - 228
• Main Authors: Tenesa, Albert, Visscher, Peter M, Carothers, Andrew D, Knott, Sara A
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.03.2005
• Subjects: Humans; Linkage Disequilibrium; Models, Genetic; Quantitative Trait Loci
• ISSN: 0001-8244; 1573-3297
• DOI: 10.1007/s10519-004-0811-5

Two approaches for mapping quantitative trait loci (QTL) using linkage disequilibrium at the population level were investigated. In the trait-based (TB) approach, the frequencies of marker alleles (or genotypes) are compared in individuals selected from the two tails of the trait distribution. The TB approach uses phenotypic information only in the selection step. In the marker-based (MB) approach, the quantitative trait values for the marker genotypes in the selected individuals are compared. The MB approach uses both the difference in marker allele (or genotype) frequencies and the phenotypic values of each marker genotype in the selected samples. We quantify the power of each approach and show that the power of the MB approach is greater than or equal to that of the TB approach. The advantage of the former is expected to increase with increasing number of traits phenotyped. Our accurate predictions obviate the need for elaborate simulation studies.