Pulmonary host defense responses to inhalation of sulfuric acid and ozone

The effects of simultaneous exposure to ozone (O3) and sulfuric acid [H2SO4, 0.23 microns volume median diameter (VMD)] and a single exposure to ultrafine (less than 0.1 micron VMD) H2SO4 under various conditions were studied using the infectivity/mortality and the ciliary beating frequency model sy...

Full description

Saved in:
Bibliographic Details
Published inJournal of toxicology and environmental health Vol. 10; no. 3; pp. 351 - 362
Main Authors Grose, E.C, Richards, J.H, Illing, J.W, Miller, F.J, Davies, D.W
Format Journal Article
LanguageEnglish
Published United States 01.09.1982
Subjects
Aerosols
air pollution
Animals
Cilia - drug effects
Cricetinae
Female
Humidity
Lung - immunology
Male
Mesocricetus
Mice
Ozone - toxicity
Streptococcal Infections - immunology
Streptococcus pyogenes
Sulfuric Acids - toxicity
Temperature
Online AccessGet more information

Cover

More Information
Summary:The effects of simultaneous exposure to ozone (O3) and sulfuric acid [H2SO4, 0.23 microns volume median diameter (VMD)] and a single exposure to ultrafine (less than 0.1 micron VMD) H2SO4 under various conditions were studied using the infectivity/mortality and the ciliary beating frequency model systems. A 3-h exposure to a combined aerosol of 196 micrograms O3/m3 and 483 or 241 micrograms H2SO4/m3 significantly increased the susceptibility of mice to a laboratory-induced respiratory infection. However, exposure to 543 micrograms ultrafine H2SO4/m3 for 2 h or 365 micrograms/m3 2 h/d for 5 d did not significantly affect this parameter. Upper airway response, as measured by changes in hamster tracheal ciliary beating frequency, was not affected by either a 3-h combined exposure to 196 micrograms O3/m3 and 847 micrograms H2SO4/m3 or a 2-h exposure to 458 micrograms ultrafine H2SO4/m3.
ISSN:0098-4108
1087-2620
DOI:10.1080/15287398209530258