Association between FDG uptake, CSF biomarkers and cognitive performance in patients with probable Alzheimer’s disease

• Published in: European journal of nuclear medicine and molecular imaging Vol. 36; no. 7; pp. 1090 - 1100
• Main Authors: Arlt, Sönke, Brassen, Stefanie, Jahn, Holger, Wilke, Florian, Eichenlaub, Martin, Apostolova, Ivayla, Wenzel, Fabian, Thiele, Frank, Young, Stewart, Buchert, Ralph
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.07.2009; Springer Nature B.V
• Subjects: Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Alzheimer Disease - psychology; Alzheimer's disease; Apolipoproteins E - genetics; Biomarkers - cerebrospinal fluid; Brain; Brain - diagnostic imaging; Brain - metabolism; Cardiology; Cognition; Female; Fluorodeoxyglucose F18 - metabolism; Follow-Up Studies; Genotype; Humans; Imaging; Linear Models; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Nuclear Medicine; Oncology; Original Article; Orthopedics; Positron-Emission Tomography; Probability; Proteins; Radiology; Retrospective Studies; Software; Tomography; Cerebrospinal fluid; F-Fluorodeoxyglucose; Alzheimer’s disease; Statistical parametric mapping; Positron emission tomography
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-009-1063-7

Purpose Brain imaging of FDG uptake and cerebrospinal fluid (CSF) concentration of amyloid-beta 1–42 (Aβ 1-42 ) or tau proteins are promising biomarkers in the diagnosis of Alzheimer’s disease (AD). There is still uncertainty regarding any association between decreased FDG uptake and alterations in CSF markers. Methods The relationship between FDG uptake, CSF Aβ 1-42 and total tau (T-tau), as well as the Mini-Mental State Examination (MMSE) score was investigated in 34 subjects with probable AD using step-wise linear regression. FDG uptake was scaled to the pons. Results Scaled FDG uptake was significantly reduced in the probable AD subjects compared to 17 controls bilaterally in the precuneus/posterior cingulate area, angular gyrus/inferior parietal cortex, inferior temporal/midtemporal cortex, midfrontal cortex, and left caudate. Voxel-based single-subject analysis of the probable AD subjects at p  < 0.001 (uncorrected) revealed a total volume of significant hypometabolism ranging from 0 to 452 ml (median 70 ml). The total hypometabolic volume was negatively correlated with the MMSE score, but it was not correlated with the CSF measures. VOI-based step-wise linear regression revealed that scaled FDG uptake in the precuneus/posterior cingulate was negatively correlated with CSF Aβ 1-42 . Scaled FDG uptake in the caudate was positively correlated with CSF T-tau. Conclusion The extent and local severity of the reduction in FDG uptake in probable AD subjects are associated with cognitive impairment. In addition, there appears to be a relationship between local FDG uptake and CSF biomarkers which differs between different brain regions.