Hear Pancreatic Cancer Stem Cells ROR

• Published in: Cell Vol. 177; no. 3; pp. 516 - 518
• Main Authors: Yao, Wantong, Maitra, Anirban
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.04.2019
• Subjects: Adenocarcinoma; Gene Expression Regulation; Humans; Nuclear Receptor Subfamily 1, Group F, Member 3; Pancreatic Neoplasms; Transcription Factors
• ISSN: 0092-8674; 1097-4172
• DOI: 10.1016/j.cell.2019.04.002

In this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer. In this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.