One-pot synthesis of novel pyrido[2,3-d]pyrimidines using HAp-encapsulated-γ-Fe2O3 supported sulfonic acid nanocatalyst under solvent-free conditions

• Published in: Chinese chemical letters Vol. 25; no. 10; pp. 1387 - 1391
• Main Authors: Mohsenimehr, Moona, Mamaghani, Manouchehr, Shirini, Farhad, Sheykhan, Mehdi, Moghaddam, Fatemeh Azimian
• Format: Journal Article
• Language: English
• Published: NEW YORK Elsevier B.V 01.10.2014; Elsevier
• Subjects: Chemistry; Chemistry, Multidisciplinary; Fe2O3; Nanocatalyst; One-pot; Physical Sciences; Pyrido[2,3-d]pyrimidines; Science & Technology; Three-component; γ-Fe2O3@HAp-SO3H; 一锅合成; 包封; 吡啶; 嘧啶衍生物; 无溶剂条件; 纳米催化剂; 羟基磷灰石; One-pot; Nanocatalyst; Pyrido[2,3-d]pyrimidines; Three-component; γ-Fe2O3@HAp-SO3H; gamma-Fe2O3@HAp-SO3H; 3-COMPONENT SYNTHESIS; PYRIMIDINE-DERIVATIVES; MAGNETICALLY SEPARABLE CATALYST; GREEN; NANOPARTICLES; ANTIINFLAMMATORY AGENTS; EFFICIENT; WATER
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2014.04.025

Novel pyrido[2,3-d]pyrimidine derivatives were synthesized through a one-pot three-component approach using HAp-encapsulated-γ-Fe2O3[γ-Fe2O3@HAp-SO3H]catalyzed condensation of 6-arnino-2-（methylthio or ethylthio）pyrimidin-4（3H）-one,Meldrum＇s acid and aryl aldehydes at 60 ℃ and under solvent-free conditions.In this protocol the use of nanocatalyst provided a green,useful and rapid method to generate the products in short reaction times and excellent yields（88%-94%）.