Photoinduced Ring-Opening and Phototoxicity of an Indolin-3-one Derivative

The study of a fluorescent indolin-3-one derivative is reported that, as opposed to its previously described congeners, selectively undergoes photoactivated ring-opening in apolar solvents. The excited state involved in this photoisomerization was partially deactivated by the formation of singlet ox...

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Published inChemistry : a European journal Vol. 29; no. 59; p. e202300864
Main Authors Doloczki, Susanne, Kern, Christoph, Holmberg, Karl O., Swartling, Fredrik J., Streuff, Jan, Dyrager, Christine
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 12.09.2023
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemistry, Multidisciplinary
Congeners
Cytotoxicity
Fluorescence
Lipids
Phototoxicity
Physical Sciences
Science & Technology
Singlet oxygen
PHYSICAL-PROPERTIES
DYES
HYDROGEN-ATOM ABSTRACTION
photoisomerization
DECOMPOSITION
lipid droplet accumulation
ring-opening
MEMORIES
PHENOLS
indolin-3-one
photoactivated cytotoxicity
SINGLET OXYGEN
INDOLE ALKALOIDS
PHOTOLYSIS
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Summary:The study of a fluorescent indolin-3-one derivative is reported that, as opposed to its previously described congeners, selectively undergoes photoactivated ring-opening in apolar solvents. The excited state involved in this photoisomerization was partially deactivated by the formation of singlet oxygen. Cell studies revealed lipid droplet accumulation and efficient light-induced cytotoxicity.
Bibliography:Vinnova
Swedish Research Council
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0947-6539
1521-3765
1521-3765
DOI:10.1002/chem.202300864