Correction of cortisol overreplacement ameliorates morbidities in patients with hypopituitarism: a pilot study
Context Hyporituitarism in adults is known to be associated with deleterious effects on body composition, lipid profile and quality of life (QoL). This was attributed to GH deficiency. The potential role of glucocorticoid overreplacement had never been investigated. Objective To investigate whether...
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Published in | Pituitary Vol. 11; no. 3; pp. 279 - 285 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Boston
Springer US
01.09.2008
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Context
Hyporituitarism in adults is known to be associated with deleterious effects on body composition, lipid profile and quality of life (QoL). This was attributed to GH deficiency. The potential role of glucocorticoid overreplacement had never been investigated.
Objective
To investigate whether reduction in glucocorticoid replacement dose to more physiological one could ameliorate the “AO-GHD”-attributed symptomatology in patients with hypopituitarism.
Design
Eleven patients with panhypopituitarism taking 20–30 mg/day of hydrocortisone, but on no GH replacement were switched to 10–15 mg of hydrocortisone daily. Both basally and 6–12 months later, their body mass index, body composition by dual-energy X-ray absorptiometry, lipid profile, and the score of quality of life, QOL-AGHDA were measured.
Results
Within 6–12 months of lower hydrocortisone dose, subjects lost an average of 7.1 kg of total body fat and 4.1 kg of abdominal fat. No changes were seen in lean body mass, bone mineral content and HOMA-IR. Plasma total cholesterol and triglyceride concentrations decreased significantly (<0.05) and the QoL improved (
P
= 0.018).
Conclusions
Our pilot study suggests that decreasing the glucocorticoid replacement dose to ~15 mg/day is beneficial in terms of patients’ body composition, lipid profile and quality of life. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 1386-341X 1573-7403 |
DOI: | 10.1007/s11102-008-0126-2 |