A microbiome-macrophage-iron axis guides stressed hematopoietic stem cell fate

The mammalian microbiota is a recently recognized regulator of hematopoiesis. In this issue of Cell Stem Cell, Zhang et al. (2022) show in mice that microbiota-derived butyrate enhances bone marrow macrophage erythrophagocytosis-dependent iron availability, which supports stress-induced hematopoieti...

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Published inCell stem cell Vol. 29; no. 2; pp. 177 - 179
Main Authors Caiado, Francisco, Manz, Markus G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 03.02.2022
Subjects
Animals
Bone Marrow
Hematopoiesis
Hematopoietic Stem Cells - cytology
Iron
Macrophages
Mammals
Mice
Microbiota
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Summary:The mammalian microbiota is a recently recognized regulator of hematopoiesis. In this issue of Cell Stem Cell, Zhang et al. (2022) show in mice that microbiota-derived butyrate enhances bone marrow macrophage erythrophagocytosis-dependent iron availability, which supports stress-induced hematopoietic stem cell differentiation and blood regeneration. The mammalian microbiota is a recently recognized regulator of hematopoiesis. In this issue of Cell Stem Cell, Zhang et al. (2022) show in mice that microbiota-derived butyrate enhances bone marrow macrophage erythrophagocytosis-dependent iron availability, which supports stress-induced hematopoietic stem cell differentiation and blood regeneration.
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ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2022.01.009