Magnetic resonance imaging findings of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in adults: a pilot study
Purpose The purpose of the study was to retrospectively analyze MRI findings of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2/TFE RCC) in adults. Methods Sixteen patients with Xp11.2/TFE RCC were reviewed retrospectively. The clinical characteristics and imaging...
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Published in | Abdominal imaging Vol. 44; no. 1; pp. 209 - 217 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.01.2019
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose
The purpose of the study was to retrospectively analyze MRI findings of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2/TFE RCC) in adults.
Methods
Sixteen patients with Xp11.2/TFE RCC were reviewed retrospectively. The clinical characteristics and imaging features were assessed and then compared between metastatic and non-metastatic subgroups.
Results
The mean age at diagnosis was 47.4 (20–76) years. Seven (44 %) patients were men, and nine (56 %) patients were women. The lesions predominantly exhibited an endophytic distribution (
n
= 14, 88 %) with a capsule (
n
= 16, 100 %), accompanied by solid and cystic patterns (
n
= 12, 75%) and hemorrhage (
n
= 11, 69 %). The tumors prevalently appeared hyper- to isointense on T1WI (
n
= 14, 88 %), hypointense on T2WI (
n
= 13, 81 %), and hyperintense on DWI (
n
= 16, 100 %) with a lower ADC (
P
< 0.001) than that of the surrounding tissue. The tumors were less enhanced than the normal renal cortex in all phases with a prolonged enhancement pattern (
P
≤ 0.001). In addition, six patients (38 %) developed recurrence or metastases. The RCCs with metastases showed an irregular shape (
P
= 0.013), an incomplete capsule (
P
= 0.018), heterogeneous solid-cystic patterns (
P
= 0.034), and hemorrhage (
P
= 0.037) than non-metastatic subgroups.
Conclusions
MRI provides valuable information for the diagnosis of adult Xp11.2/TFE RCCs. Features including irregular shape, incomplete capsule, mixed solid-cystic pattern, and hemorrhage may indicate the occurrence of recurrence or metastases. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2366-004X 2366-0058 2366-0058 |
DOI: | 10.1007/s00261-018-1703-0 |