The formulation of an effective topical antibacterial product containing Ocimum gratissimum leaf essential oil

The antibacterial potential of Ocimum gratissimum essential oil was explored. Liquid and semisolid formulations of the oil were designed in a variety of bases for topical antiseptic medication. The products were evaluated by agar diffusion assay against type strains and clinical isolates from boil,...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of pharmaceutics Vol. 224; no. 1-2; pp. 177 - 183
Main Authors ORAFIDIYA, Lara O, OYEDELE, A. O, SHITTU, A. O, ELUJOBA, A. A
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier 14.08.2001
Subjects
Anti-Infective Agents, Local - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - drug effects
Biological and medical sciences
Excipients
General pharmacology
Humans
Medical sciences
Microbial Sensitivity Tests
Ocimum basilicum - chemistry
Ointments
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Plant Leaves - chemistry
Plant Oils - pharmacology
Plants, Medicinal - chemistry
Proteus - drug effects
Pseudomonas aeruginosa - drug effects
Solutions - chemistry
Staphylococcus aureus - drug effects
Pseudomonadales
Human
Pharmaceutical technology
Liquid solution
Surfactant
Solid solution
In vitro
Biological activity
Dispersion
Sensitivity resistance
Dosage form
Bacteria
Micrococcales
Pseudomonadaceae
Pseudomonas aeruginosa
Micrococcaceae
Essential oil
Antibacterial agent
Clinical isolate
Staphylococcus aureus
Online AccessGet full text

Cover

More Information
Summary:The antibacterial potential of Ocimum gratissimum essential oil was explored. Liquid and semisolid formulations of the oil were designed in a variety of bases for topical antiseptic medication. The products were evaluated by agar diffusion assay against type strains and clinical isolates from boil, wound and pimples. Remarkable antibacterial effects, higher than those of commercial antiseptic products, were demonstrated at 2% Ocimum oil concentration in some bases. The properties of base into which the oil was incorporated affected its activity. It was more effective in hydrophilic bases than in lipophilic bases. Solubilization and microemulsification grossly reduced its activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-5173
1873-3476
DOI:10.1016/s0378-5173(01)00764-5