Radiology Profile as a Potential Instrument to Differentiate Between Posterior Fossa Ependymoma (PF-EPN) Group A and B

• Published in: World neurosurgery Vol. 140; pp. e320 - e327
• Main Authors: Yonezawa, Ushio, Karlowee, Vega, Amatya, Vishwa Jeet, Takayasu, Takeshi, Takano, Motoki, Takeshima, Yukio, Sugiyama, Kazuhiko, Kurisu, Kaoru, Yamasaki, Fumiyuki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2020
• Subjects: Adolescent; Adult; Aged; Child; Child, Preschool; Contrast rate; Diffusion Magnetic Resonance Imaging - methods; Ependymoma - classification; Ependymoma - diagnostic imaging; Ependymoma - pathology; Female; H3K27me3; Humans; Image Interpretation, Computer-Assisted - methods; Infant; Infratentorial Neoplasms - classification; Infratentorial Neoplasms - diagnostic imaging; Infratentorial Neoplasms - pathology; Male; Middle Aged; MR image; Neuroimaging - methods; Posterior fossa ependymoma; Progression-Free Survival; Retrospective Studies; Tomography, X-Ray Computed - methods; ADC; Contrast rate; EPN; OS; MRI; Posterior fossa ependymoma; T1WI; MR image; CT; PF; T2WI; DWI; FLAIR; PFS; Gd; H3K27me3; WHO
• ISSN: 1878-8750; 1878-8769
• DOI: 10.1016/j.wneu.2020.05.063

Posterior fossa ependymoma (PF-EPN) was categorized into PF-EPN-A and PF-EPN-B subgroups based on the DNA methylation profiling. PF-EPN-A was reported to have poorer prognosis compared with PF-EPN-B. In this study, we particularly evaluated preoperative imaging to distinguish PF-EPN-A from PF-EPN-B. Sixteen cases of PF-EPN were treated in our institution from 1999 to 2018. The patients were divided into PF-EPN-A and PF-EPN-B groups based on H3K27me3 immunostaining positivity. We evaluated progression-free survival, overall survival, as well as preoperative magnetic resonance imaging and computed tomography scan images in both groups. Based on T1WI and Gd-T1WI magnetic resonance images, the tumor contrast rate was determined from dividing the volume of gadolinium enhanced tumor by the overall tumor volume. Nine cases (4 male, 5 female) were grouped as PF-EPN-A, and 7 (4 male, 3 female) as PF-EPN-B. The median age of PF-EPN-A and PF-EPN-B were 4 and 43 years old, respectively. In the PF-EPN-A group, the progression-free survival median value was 32.6 months, and the overall survival median was 96.9 months. In contrast, PFS in PF-EPN-B did not reach a median value (P < 0.05) and all the patients were alive (P < 0.05) at the end of the study. With imaging, tumor contrast rate in PF-EPN-B was more than 50% and significantly different from PF-EPN-A (P = 0.0294). Calcification was mainly observed in PF-EPN-A, whereas cystic formation was only seen in PF-EPN-B. Contrast rate less than 50%, based on the magnetic resonance images, was characteristic in the PF-EPN-A group. Comparatively, cystic component and absence of calcification were more characteristic in the PF-EPN-B group.