A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors

A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis an...

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Published inBioorganic & medicinal chemistry letters Vol. 10; no. 11; pp. 1223 - 1226
Main Authors OWA, T, OKAUCHI, T, YOSHIMATSU, K, SUGI, N. H, OZAWA, Y, NAGASU, T, KOYANAGI, N, OKABE, T, KITOH, K, YOSHINO, H
Format Journal Article
LanguageEnglish
Published Oxford Elsevier 05.06.2000
Subjects
Antineoplastic agents
Biological and medical sciences
Cell Cycle - drug effects
Drug Screening Assays, Antitumor
General aspects
Humans
Medical sciences
Pharmacology. Drug treatments
Sulfonamides - chemistry
Sulfonamides - pharmacology
Tumor Cells, Cultured
Antineoplastic agent
Human
Sulfonamide
Nitrogen heterocycle
P388-Leukemia
Nasopharynx
G1 Phase
Cell line
Structure activity relation
Animal
KB cell line
Chemical compound library
Cell cycle
Bicyclic compound
Aromatic compound
Colon
Indole derivatives
Chemical synthesis
Antimitotic
Tumor cell
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Summary:A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/s0960-894x(00)00219-5