Blood cell generation from the hemangioblast

• Published in: Journal of molecular medicine (Berlin, Germany) Vol. 88; no. 2; pp. 167 - 172
• Main Authors: Lancrin, Christophe, Sroczynska, Patrycja, Serrano, Alicia G., Gandillet, Arnaud, Ferreras, Cristina, Kouskoff, Valerie, Lacaud, Georges
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2010; Springer; Springer Nature B.V
• Subjects: Animals; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Blood Cells - cytology; Blood Cells - metabolism; Cell Differentiation; Cell Lineage; General aspects; Hemangioblasts - cytology; Hematologic and hematopoietic diseases; Hematopoiesis; Human Genetics; Humans; Internal Medicine; Leukemia - physiopathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Mice; Molecular Medicine; Review; Transcription Factors - metabolism; Transcription factors; Hemangioblast; Hematopoiesis; Leukemia; Hemogenic endothelium; Stem cells; Stem cell; Malignant hemopathy; Endothelium; Medicine; Signal transduction; Blood cell; Transcription factor; Cancer
• ISSN: 0946-2716; 1432-1440
• DOI: 10.1007/s00109-009-0554-0

Understanding how blood cells are generated is important from a biological perspective but also has potential implications in the treatment of blood diseases. Such knowledge could potentially lead to defining new conditions to amplify hematopoietic stem cells (HSCs) or could translate into new methods to produce HSCs, or other types of blood cells, from human embryonic stem cells or induced pluripotent stem cells. Additionally, as most key transcription factors regulating early hematopoietic development have also been implicated in various types of leukemia, understanding their function during normal development could result in a better comprehension of their roles during abnormal hematopoiesis in leukemia. In this review, we discuss our current understanding of the molecular and cellular mechanisms of blood development from the earliest hematopoietic precursor, the hemangioblast, a precursor for both endothelial and hematopoietic cell lineages.