Life and death agendas of actin filaments

Cancer cells have now been shown to lack rigidity-sensing due to alteration in cytoskeletal sensor proteins, but can be reversed from a transformed to a rigidity-dependent growth state by the sensor proteins, resulting in restoration of contractility and adhesion.

Saved in:
Bibliographic Details
Published inNature materials Vol. 19; no. 2; pp. 135 - 136
Main Authors Hardeman, Edna C, Gunning, Peter W
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.02.2020
Subjects
Actin Cytoskeleton
Actins
Apoptosis
Cancer
Cell growth
Electric fields
Filaments
Kinases
Laboratories
Proteins
Restoration
Rigidity
Robotics
Sensors
Online AccessGet full text

Cover

More Information
Summary:Cancer cells have now been shown to lack rigidity-sensing due to alteration in cytoskeletal sensor proteins, but can be reversed from a transformed to a rigidity-dependent growth state by the sensor proteins, resulting in restoration of contractility and adhesion.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Commentary-1
ISSN:1476-1122
1476-4660
DOI:10.1038/s41563-019-0583-1