Editorial: Ion Channels: Therapeutic Targets for Neurological Disease

• Published in: Frontiers in molecular neuroscience Vol. 14; p. 797327
• Main Authors: Hou, Panpan, Du, Xiaona, An, Hailong
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 16.11.2021; Frontiers Media S.A
• Subjects: Alzheimer's disease; drug target; Environmental effects; Free radicals; Hearing loss; Ion channels; Ion channels (ligand-gated); Ions; Ischemia; Mental disorders; Molecular Neuroscience; Mutation; Nervous system; neurological disease; Neurological diseases; Neurological disorders; Osmolarity; Oxidative stress; Pain; Pathophysiology; Reperfusion; Schizophrenia; single nucleotide polymorphism (SNP); Spinal cord injuries; spinal cord injury (SCI); Therapeutic applications; Therapeutic targets; Transient receptor potential proteins; Voltage; United States > US; China
• ISSN: 1662-5099; 1662-5099
• DOI: 10.3389/fnmol.2021.797327

The prevalence of most neurological disorders increases with age, and the lack of effective treatment options continues to increase the number of patients (Feigin et al., 2019). [...]developing new strategies to prevent and treat the major neurological disorders is of great importance to improve human health. Dysfunction of ion channels by inherited mutations, pathological changes, or unwanted drug-induced side effects can alter ion flux across the membrane and cause neurological disorders. In this topic named “Ion Channels: Therapeutic Targets for Neurological Disease,” we collect and summarize the most recent studies including four original articles and two reviews focusing on ion channel modulation mechanisms and ion channels as potential targets for treating hearing loss, pain, spinal cord injury, ischemia-reperfusion injury, and schizophrenia. Unlike voltage-gated ion channels that sense the membrane voltage change via the voltage sensing domain (Wang et al., 2017; Hou et al., 2020), the transient receptor potential channels (TRP channels) are ligand-gated ion channels that are sensitive to physical (heat, pH, osmolarity, etc.) and chemical (ligands, Ca2+, etc.) stimuli from the environment, and therefore are important sensors for perception (Clapham, 2003).