Effect of t (11;14) Abnormality on Outcomes of Patients With Newly Diagnosed Multiple Myeloma in the Connect MM Registry

• Published in: Clinical lymphoma, myeloma and leukemia Vol. 22; no. 3; pp. 149 - 157
• Main Authors: Gasparetto, Cristina, Jagannath, Sundar, Rifkin, Robert M., Durie, Brian G.M., Narang, Mohit, Terebelo, Howard R., Toomey, Kathleen, Hardin, James W., Wagner, Lynne, Ailawadhi, Sikander, Omel, James L., Srinivasan, Shankar, Dhalla, Mazaher, Catamero, Donna, Kitali, Amani, Agarwal, Amit, Abonour, Rafat
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2022
• Subjects: African American; African Americans; Community; Humans; Multiple Myeloma - diagnosis; Multiple Myeloma - drug therapy; Multiple Myeloma - genetics; Proportional Hazards Models; Prospective Studies; Real-world; Registries; Retrospective Studies; Survival; Translocation; Translocation; Survival; Community; Real-world; African American
• ISSN: 2152-2650; 2152-2669
• DOI: 10.1016/j.clml.2021.08.007

The t (11;14) (q13;32) translocation [t (11;14)] is present in ∼20% of patients with newly diagnosed multiple myeloma (NDMM), but studies examining its prognostic ability have yielded divergent results, and data are lacking on outcomes from first-line therapy. Data from the Connect MM Registry, a large US, multicenter, prospective observational cohort study of patients with NDMM were used to examine the effect of t (11;14) status on first-line therapy outcomes in the Overall population (n = 1574) and race groups (African American [AA] vs. non-African American [NAA]). Baseline characteristics were generally similar between patients with (n = 378) and without (n = 1196) t (11;14). Prevalence of t (11;14) was similar by race (AA, 27%; NAA, 24%). In the overall population, regardless of first-line therapy, t (11;14) status did not affect progression-free survival (hazard ratio, 1.02; P = 0.7675) or overall survival (hazard ratio, 0.99; P = .9417). AA patients with t (11;14) had higher likelihood of death (Nominal Cox regression P = .0298) vs. patients without t (11;14). Acknowledging observational study and inferential limitations, this exploratory analysis of a predominantly community-based population suggests that t (11;14) is a neutral prognostic factor in the general MM population but may be a negative factor for overall survival in AA patients. Connect MM Registry is a large, US, multicenter (84% community-based), prospective observational cohort study where the effect of t (11;14) status on first-line therapy outcomes was examined in the newly diagnosed multiple myeloma population. Exploratory analysis results suggest t (11;14) is a neutral prognostic factor in the overall population but may negatively affect overall survival in African American patients.