Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms

• Published in: Toxicology and applied pharmacology Vol. 474; p. 116623
• Main Authors: Kumar, Vinay, Sharma, Neha, Sharma, Preeti, Pasrija, Ritu, Kaur, Komalpreet, Umesh, Mridul, Thazeem, Basheer
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2023
• Subjects: Biochemical mechanisms; Endocrine disruptors; Genotoxicity; Neurotoxicity; Non-target toxicity; Endocrine disruptors; Neurotoxicity; Biochemical mechanisms; Non-target toxicity; Genotoxicity
• ISSN: 0041-008X; 1096-0333
• DOI: 10.1016/j.taap.2023.116623

Endocrine disrupting compounds are the chemicals which mimics the natural endocrine hormones and bind to the receptors made for the hormones. Upon binding they activate the cascade of reaction which leads to permanent activating of the signalling cycle and ultimately leads to uncontrolled growth. Pesticides are one of the endocrine disrupting chemicals which cause cancer, congenital birth defects, and reproductive defects in non-target organisms. Non-target organisms are keen on exposing to these pesticides. Although several studies have reported about the pesticide toxicity. But a critical analysis of pesticide toxicity and its role as endocrine disruptor is lacking. Therefore, the presented review literature is an endeavour to understand the role of the pesticides as endocrine disruptors. In addition, it discusses about the endocrine disruption, neurological disruption, genotoxicity, and ROS induced pesticide toxicity. Moreover, biochemical mechanisms of pesticide toxicity on non-target organisms have been presented. An insight on the chlorpyrifos toxicity on non-target organisms along with species names have been presented. [Display omitted] •Role of pesticide as endocrine disrupting chemicals was explored.•The non-target toxicity of pesticides was analysed.•Toxicity mechanisms such as genotoxicity, neurological disruption and ROS induced toxicity is explained.•Toxicity data on available non-target organisms such as crustaceans and amphibian was analysed.