Association of Longitudinal B-Type Natriuretic Peptide Monitoring With Kidney Failure in Patients With CKD: A Cohort Study

• Published in: American journal of kidney diseases Vol. 82; no. 5; pp. 559 - 568
• Main Authors: Oka, Tatsufumi, Sakaguchi, Yusuke, Hattori, Koki, Asahina, Yuta, Kajimoto, Sachio, McCallum, Wendy, Tighiouart, Hocine, Sarnak, Mark J., Kaimori, Jun-Ya, Isaka, Yoshitaka
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2023
• Subjects: Acute kidney injury (AKI); Acute Kidney Injury - blood; Acute Kidney Injury - diagnosis; Acute Kidney Injury - epidemiology; Acute Kidney Injury - etiology; Aged; B-type natriuretic peptide (BNP); Biomarkers - blood; chronic kidney disease (CKD); Cohort Studies; Disease Progression; Female; fluid management; Glomerular Filtration Rate; heart failure; Heart Failure - blood; Heart Failure - epidemiology; Humans; kidney failure; kidney replacement therapy (KRT); longitudinal monitoring; Longitudinal Studies; Male; Middle Aged; Natriuretic Peptide, Brain - blood; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - therapy; Renal Replacement Therapy; Retrospective Studies; heart failure; fluid management; longitudinal monitoring; Acute kidney injury (AKI); kidney failure; kidney replacement therapy (KRT); chronic kidney disease (CKD); B-type natriuretic peptide (BNP)
• ISSN: 0272-6386; 1523-6838; 1523-6838
• DOI: 10.1053/j.ajkd.2023.05.003

Both hypervolemia and hypovolemia are associated with chronic kidney disease (CKD) progression. Although longitudinal monitoring of B-type natriuretic peptide (BNP) may aid physicians’ decision making about the optimization of volume status, its clinical benefit remains uncertain in CKD. This study assessed the association between BNP monitoring and the risk of incident kidney replacement therapy (KRT). Retrospective cohort study. A total of 2,998 outpatients with stages 3-5 of nondialyzed CKD referred to the department of nephrology at an academic hospital. BNP monitoring. KRT, acute kidney injury (AKI), and heart failure hospitalization. Marginal structural models, which create a balanced pseudo population at each time point, were applied to account for potential time-dependent confounders. Inverse probability weighted pooled logistic regression models were employed to estimate hazard ratios. At baseline, the median age and estimated glomerular filtration rate were 66 years and 38.1mL/min/1.73m2, respectively. During the follow-up period (median, 5.9 [IQR, 2.8-9.9] years), 449 patients required KRT, 765 had AKI, and 236 were hospitalized for heart failure. After adjustment for time-updated clinical characteristics and physician-specific practice styles, BNP monitoring was associated with lower risks of KRT (HR, 0.44 [95% CI, 0.21-0.92]), AKI (HR, 0.36 [95% CI, 0.18-0.72]), and heart failure hospitalization (HR, 0.37 [95% CI, 0.14-0.95]). The association between BNP monitoring and KRT was attenuated after additional adjustment for AKI or heart failure hospitalization as a time-varying covariate. Residual confounding by measured and unmeasured variables or indications for BNP measurements. BNP monitoring was associated with a lower risk of KRT among patients with CKD that did not require dialysis. This association is potentially mediated through a reduced risk of AKI or heart failure hospitalization. Both volume overload and volume depletion are deleterious to kidney function. B-type natriuretic peptide (BNP) is a biomarker that reflects volume status not only in heart failure but also in nondialysis chronic kidney disease (CKD). Although longitudinal BNP monitoring may aid physicians’ decision making about the optimization of volume status, its clinical benefit remains uncertain in CKD. In this cohort study analyzing 2,998 patients with nondialyzed CKD, BNP monitoring was associated with a lower risk of kidney replacement therapy, acute kidney injury, and heart failure hospitalization over the follow-up period. The association with kidney replacement therapy may be mediated through a reduced risk of acute kidney injury or heart failure hospitalization. BNP monitoring may aid physicians in optimal fluid management, potentially conferring better kidney outcomes.