Synthesis of novel, azasugar-modified anthraquinone derivatives and their cytotoxicity

A series of novel, azasugar-modified 2-monosubstituted, 2,6- and 2,7-bissubstituted anthraquinone derivatives have been synthesized by the nucleophilic substitution of N-alkylamino azasugar with mono-, bis（2-chloroacetamido）anthraquinones. Their cytotoxic activities against HeLa and MCF-7 ceils were...

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Bibliographic Details
Published inChinese chemical letters Vol. 25; no. 7; pp. 1057 - 1059
Main Authors Zhang, Ping-Zhu, Yang, Hai-Long, Li, Cui-Cui, Xia, Zhi-Chao, Wang, Xiao-Man, Wei, Hua, Rong, Rui-Xue, Cao, Zhi-Ran, Wang, Ke-Rang, Chen, Hua, Li, Xiao-Liu
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.07.2014
Subjects
Anthraquinone
Azasugar
Cytotoxic activity
修饰
单糖
合成
氮杂
细胞毒性
细胞毒活性
蒽醌类化合物
蒽醌衍生物
Azasugar
Anthraquinone
Cytotoxic activity
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Summary:A series of novel, azasugar-modified 2-monosubstituted, 2,6- and 2,7-bissubstituted anthraquinone derivatives have been synthesized by the nucleophilic substitution of N-alkylamino azasugar with mono-, bis（2-chloroacetamido）anthraquinones. Their cytotoxic activities against HeLa and MCF-7 ceils were preliminarily evaluated and compound 9a with mono-azasugar pendant at 2-position showed similar activity to the control drug （Cisplatin）.
Bibliography:A series of novel, azasugar-modified 2-monosubstituted, 2,6- and 2,7-bissubstituted anthraquinone derivatives have been synthesized by the nucleophilic substitution of N-alkylamino azasugar with mono-, bis（2-chloroacetamido）anthraquinones. Their cytotoxic activities against HeLa and MCF-7 ceils were preliminarily evaluated and compound 9a with mono-azasugar pendant at 2-position showed similar activity to the control drug （Cisplatin）.
Anthraquinone;Azasugar;Cytotoxic activity
11-2710/O6
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2014.05.029