Synthesis and characterization of anti-adhesion tricomposite electrospun nanofiber barrier membrane for use in post-surgical adhesion conditions

• Published in: Materials letters Vol. 285; p. 129038
• Main Authors: Sathish, P.B., Narmadha, R., Selvakumar, R.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.02.2021; Elsevier BV
• Subjects: Adhesion; Biocompatibility; Biomaterials; Contact angle; Electrospinning; Materials science; Membranes; Nanofibers; Polycaprolactone (PCL); Polymeric composites; Post-surgical adhesion; Potential barriers; Strain; Synthesis; Tricomposite nanofibers; Polymeric composites; Tricomposite nanofibers; Polycaprolactone (PCL); Biomaterials; Post-surgical adhesion
• ISSN: 0167-577X; 1873-4979
• DOI: 10.1016/j.matlet.2020.129038

[Display omitted] •Novel anti-adhesion tricomposite electrospun nanofibers membrane synthesized as barrier membrane.•The barrier membranes showed superior properties suitable for use as anti-adhesion barrier membranes.•It can be used as an alternative to address the drawbacks of currently available barrier membranes. Adhesion formation is a crucial post-surgical problem that needs to be addressed by clinicians. In this study, we report the synthesis of a novel tricomposite electrospun nanofiber membrane as a potential barrier for the prevention of post-surgical adhesion. The synthesized membrane was characterized using suitable techniques. The membrane showed excellent hydrophilicity (15.2° contact angle), mechanical stability (5.04 MPa with a strain of 50%) and biocompatibility (cell viability of 106%) required for a potential barriers membrane to be used in post adhesion surgical condition. This membrane can be an alternative membrane to address the drawbacks of currently used antiadhesion barrier membrane.