Oxytocin: physiology, pharmacology, and clinical application for labor management

• Published in: American journal of obstetrics and gynecology Vol. 230; no. 3; pp. S729 - S739
• Main Authors: Hermesch, Amy C., Kernberg, Annessa S., Layoun, Vanessa R., Caughey, Aaron B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2024
• Subjects: augmentation; childhood neurodevelopmental disorders; chorioamnionitis; induction of labor; infusion protocols; oxytocin; oxytocin checklist; Pitocin; postpartum hemorrhage; postpartum mood disorders; tachysystole; water intoxication; postpartum hemorrhage; tachysystole; Pitocin; induction of labor; oxytocin; oxytocin checklist; postpartum mood disorders; water intoxication; augmentation; childhood neurodevelopmental disorders; chorioamnionitis; infusion protocols
• ISSN: 0002-9378; 1097-6868; 1097-6868
• DOI: 10.1016/j.ajog.2023.06.041

Oxytocin is a peptide hormone that plays a key role in regulating the female reproductive system, including during labor and lactation. It is produced primarily in the hypothalamus and secreted by the posterior pituitary gland. Oxytocin can also be administered as a medication to initiate or augment uterine contractions. To study the effectiveness and safety of oxytocin, previous studies have randomized patients to low- and high-dose oxytocin infusion protocols either alone or as part of an active management of labor strategy along with other interventions. These randomized trials demonstrated that active management of labor and high-dose oxytocin regimens can shorten the length of labor and reduce the incidence of clinical chorioamnionitis. The safety of high-dose oxytocin regimens is also supported by no associated differences in fetal heart rate abnormalities, postpartum hemorrhage, low Apgar scores, neonatal intensive care unit admissions, and umbilical artery acidemia. Most studies reported no differences in the cesarean delivery rates with active management of labor or high-dose oxytocin regimens, thereby further validating its safety. Oxytocin does not have a predictable dose response, thus the pharmacologic effects and the amplitude and frequency of uterine contractions are used as physiological parameters for oxytocin infusion titration to achieve adequate contractions at appropriate intervals. Used in error, oxytocin can cause patient harm, highlighting the importance of precise administration using infusion pumps, institutional safety checklists, and trained nursing staff to closely monitor uterine activity and fetal heart rate changes. In this review, we summarize the physiology, pharmacology, infusion regimens, and associated risks of oxytocin.