A Case of Heart Transplantation for Fulminant Myocarditis After ChAdOx1 nCoV-19 Vaccination

Vaccines have become the mainstay of management against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019; COVID-19) in the absence of effective antiviral therapy. Various adverse effects of COVID-19 vaccination have been reported, including cardiovascu...

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Published inJournal of Korean medical science Vol. 37; no. 13; pp. e104 - 6
Main Authors Kim, Seok Hyun, Lee, Soo Yong, Kim, Ga Yun, Oh, Ji Soo, Kim, Jeongsu, Chun, Kook Jin, Ju, Min Ho, Lee, Chee-Hoon, Song, Yeo-Jeong, Na, Joo-Young
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Academy of Medical Sciences 04.04.2022
대한의학회
Subjects
Case Report
ChAdOx1 nCoV-19
COVID-19
COVID-19 Vaccines - adverse effects
Female
Heart Transplantation - adverse effects
Humans
Myocarditis - complications
Myocarditis - etiology
SARS-CoV-2
Vaccination - adverse effects
의학일반
COVID-19
Myocarditis
ChAdOx1 nCoV-19 Vaccine
AstraZeneca
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Summary:Vaccines have become the mainstay of management against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019; COVID-19) in the absence of effective antiviral therapy. Various adverse effects of COVID-19 vaccination have been reported, including cardiovascular complications such as myocarditis or pericarditis. Herein, we describe clinical records of a 63-year woman with fulminant myocarditis following ChAdOx1 nCoV-19 vaccination that was salvaged by heart transplantation. She complained chest pain, nausea, vomiting, and fever after the second vaccination. After the heart transplantation, the patient died due to necrotizing pneumonia on the 54th day of onset. Fulminant myocarditis is very rare after ChAdOx1 nCoV-19 vaccination but can be fatal.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2022.37.e104