Solvent-free synthesis of pillar[6]arenes

An efficient solvent-free procedure for the synthesis of pillar[6]-arenes has been developed. The procedure involves the solid-state condensation of finely milled 1,4-dialkoxybenzene and paraformaldehyde by grinding in the presence of a catalytic amount of H2SO4. The use of organic solvents for the...

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Published inGreen chemistry : an international journal and green chemistry resource : GC Vol. 18; no. 2; pp. 423 - 426
Main Authors Santra, S., Kopchuk, D. S., Kovalev, I. S., Zyryanov, G. V., Majee, A., Charushin, V. N., Chupakhin, O. N.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2016
Subjects
Catalysis
Catalysts
Chemistry
Chemistry, Multidisciplinary
Compatibility
Extraction
Green & Sustainable Science & Technology
Methodology
Physical Sciences
Purification
Science & Technology
Science & Technology - Other Topics
Solvents
Synthesis
PILLARARENES
HOST
CHANNELS
DRIVEN
FACILE
HIGH-YIELD SYNTHESIS
INCLUSION COMPLEX
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Summary:An efficient solvent-free procedure for the synthesis of pillar[6]-arenes has been developed. The procedure involves the solid-state condensation of finely milled 1,4-dialkoxybenzene and paraformaldehyde by grinding in the presence of a catalytic amount of H2SO4. The use of organic solvents for the extraction of products has also been avoided. Operational simplicity, compatibility with various 1,4-dialkoxybenzenes, non-chromatographic purification technique, high yields and mild reaction conditions are the notable advantages of this procedure. A large scale reaction demonstrated the practical applicability of this methodology.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1463-9262
1463-9270
DOI:10.1039/c5gc01505g