The growing applications of click chemistry

Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy relies mainly upon the construction of carbon-heteroatom bonds using spring-loaded reactants. Its growing number of applications are found in n...

Full description

Saved in:
Bibliographic Details
Published inChemical Society reviews Vol. 36; no. 8; p. 1249
Main Authors Moses, John E, Moorhouse, Adam D
Format Journal Article
LanguageEnglish
Published England 10.07.2007
Subjects
Alkynes - chemistry
Azides - chemistry
Catalysis
Combinatorial Chemistry Techniques - methods
Copper - chemistry
Cross-Linking Reagents
Drug Design
Triazoles - chemistry
Online AccessGet more information

Cover

More Information
Summary:Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy relies mainly upon the construction of carbon-heteroatom bonds using spring-loaded reactants. Its growing number of applications are found in nearly all areas of modern chemistry from drug discovery to materials science. The copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.
ISSN:0306-0012
DOI:10.1039/b613014n