Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing

• Published in: European journal of pharmaceutics and biopharmaceutics Vol. 123; pp. 42 - 49
• Main Authors: Liu, Xiaoli, Nielsen, Line Hagner, Kłodzińska, Sylvia Natalie, Nielsen, Hanne Mørck, Qu, Haiyan, Christensen, Lars Porskjær, Rantanen, Jukka, Yang, Mingshi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2018
• Subjects: Alginates - chemistry; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - chemistry; Antimicrobial activity; Bandages; Ciprofloxacin - administration & dosage; Ciprofloxacin - chemistry; Electrospinning; Glucuronic Acid - chemistry; Hexuronic Acids - chemistry; Hydrodynamic methods; Hydrophilicity; Hydrophobic and Hydrophilic Interactions; Lactic Acid - chemistry; Mechanical properties; Polyglycolic Acid - chemistry; Water-solid interactions; Wound Healing - drug effects; Electrospinning; Mechanical properties; Hydrodynamic methods; Antimicrobial activity; Hydrophilicity; Water-solid interactions
• ISSN: 0939-6411; 1873-3441
• DOI: 10.1016/j.ejpb.2017.11.004

[Display omitted] Wound dressings should ideally be able to maintain high humidity, remove excess wound exudate, permit thermal insulation, provide certain mechanical strength, and in some cases deliver antibiotics to prevent infections. Until now, none of the existing wound dressing products can meet all these requirements. To design a wound dressing with as many of the aforementioned features as possible, in this study, we attempted to prepare ciprofloxacin (CIP), an antibiotic, loaded electrospun hydrophobic poly (lactic-co-glycolic acid) (PLGA) fibrous mats modified with hydrophilic sodium alginate (ALG) microparticles. The results showed that ALG could improve the wettability, water absorption capacity, and enhance the release rate of ciprofloxacin from the PLGA fibrous mats. In addition, the addition of ALG reduced the stiffness of PLGA fibrous mats for better protection of the injured area as indicated by the Young’s modulus. Moreover, the burst release of CIP resulted from the addition of ALG seemed to provide an improved antimicrobial effect to the PLGA mats. This study demonstrated the potential of combining hydrophilic and hydrophobic polymers to design the desired wound dressings via the electrospinning process.