Hypertension-misattributed kidney disease in African Americans

Lipkowitz et al. extend the African American Study of Kidney Disease and Hypertension to the level of genetic epidemiology, in a case–control study design. Analysis of genotypes at the APOL1 kidney disease risk region supports a paradigm shift in which genetic risk is proximate to both kidney diseas...

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Bibliographic Details
Published inKidney international Vol. 83; no. 1; pp. 6 - 9
Main Authors Skorecki, Karl L., Wasser, Walter G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2013
Elsevier Limited
Subjects
African Americans - ethnology
African Americans - genetics
Apolipoprotein L1
Apolipoproteins - genetics
Female
Genetic Variation - genetics
Humans
Hypertension, Renal - ethnology
Hypertension, Renal - genetics
Kidney - physiopathology
Lipoproteins, HDL - genetics
Male
Nephritis - ethnology
Nephritis - genetics
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Summary:Lipkowitz et al. extend the African American Study of Kidney Disease and Hypertension to the level of genetic epidemiology, in a case–control study design. Analysis of genotypes at the APOL1 kidney disease risk region supports a paradigm shift in which genetic risk is proximate to both kidney disease and hypertension. The findings mandate urgency in clarifying mechanisms whereby APOL1 region risk variants interact with environmental triggers to cause progressive kidney disease accompanied by dangerous hypertension.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:0085-2538
1523-1755
DOI:10.1038/ki.2012.369