Livedoid vasculopathy associated with combined prothrombin G20210A and factor V (Leiden) heterozygosity and MTHFR C677T homozygosity

Livedoid vasculopathy (LV) is an occlusive thrombotic disease of lower extremities. A 34-year-old woman presented with 4-year history of recurrent necrotic and painful lesions with violaceous and purpuric border on both legs. Initial treatment with hydroxychloroquine, dapsone and prednisone were uns...

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Bibliographic Details
Published inJournal of thrombosis and thrombolysis Vol. 26; no. 1; pp. 31 - 34
Main Authors Irani-Hakime, Noha A., Stephan, Farid, Kreidy, Raghid, Jureidini, Isabelle, Almawi, Wassim Y.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.08.2008
Springer Nature B.V
Subjects
Adult
Analgesics - therapeutic use
Anti-Inflammatory Agents - therapeutic use
Anticoagulants - therapeutic use
Blood Coagulation - genetics
Cardiology
Drug Therapy, Combination
Factor V - genetics
Female
Hematology
Heterozygote
Homozygote
Humans
Hyperhomocysteinemia - genetics
Livedo Reticularis - blood
Livedo Reticularis - diagnosis
Livedo Reticularis - drug therapy
Livedo Reticularis - genetics
Livedo Reticularis - pathology
Medicine
Medicine & Public Health
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Prothrombin - genetics
Treatment Outcome
Factor V-Leiden
MTHFR C677T
Livedoid vasculopathy
Prothrombin G20210A
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Summary:Livedoid vasculopathy (LV) is an occlusive thrombotic disease of lower extremities. A 34-year-old woman presented with 4-year history of recurrent necrotic and painful lesions with violaceous and purpuric border on both legs. Initial treatment with hydroxychloroquine, dapsone and prednisone were unsuccessful. Skin biopsy showed inflammatory infiltrate with epidermal necrosis. Prothrombin G20210A and factor V-Leiden heterozygosity, and MTHFR C677T homozygosity with hyperhomocysteinemia were confirmed. LV diagnosis was made; acetylsalicylic acid, folic acid, vitamin B12, and prednisone treatement resulted in complete healing. This is the first report on coexistence of prothrombin G20210A, factor V-Leiden, and homozygous MTHFR C677T with hyperhomocysteinemia in LV.
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ISSN:0929-5305
1573-742X
DOI:10.1007/s11239-008-0214-1