Pleural mesothelial sequestration of iron in the rat

Examination of morphology and iron deposition in pulmonary tissue from rats loaded with parenteral iron demonstrated a significant increase (compared to controls) of iron in pleural lining cells. No significant differences were noted in iron deposition in macrophages or in lung parenchyma. These res...

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Bibliographic Details
Published inPathology Vol. 16; no. 2; p. 124
Main Authors May, E E, May, M E
Format Journal Article
LanguageEnglish
Published England 01.01.1984
Subjects
Animals
Hemochromatosis - pathology
Iron - metabolism
Lung - metabolism
Lung - pathology
Macrophages - ultrastructure
Male
Pleura - pathology
Rats
Rats, Inbred Strains
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Summary:Examination of morphology and iron deposition in pulmonary tissue from rats loaded with parenteral iron demonstrated a significant increase (compared to controls) of iron in pleural lining cells. No significant differences were noted in iron deposition in macrophages or in lung parenchyma. These results suggest that the pleural surface may represent an unrecognized target tissue in hemochromatosis.
ISSN:0031-3025
DOI:10.3109/00313028409059088