Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

Our work has shown that certain ruthenium(II) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimisi...

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 38; p. 4764
Main Authors Yan, Yaw Kai, Melchart, Michael, Habtemariam, Abraha, Sadler, Peter J
Format Journal Article
LanguageEnglish
Published England 14.10.2005
Subjects
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Benzene Derivatives - chemistry
DNA - drug effects
Drug Design
Humans
Molecular Structure
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Proteins - chemistry
Proteins - drug effects
Ruthenium - chemistry
Stereoisomerism
Structure-Activity Relationship
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Summary:Our work has shown that certain ruthenium(II) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimising side-effects by variations in the arene and the other coordinated ligands. Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reactions of Ru(II) arene complexes with biomolecules can be achieved. These Ru(II) arene complexes appear to have an altered profile of biological activity in comparison with metal-based anticancer complexes currently in clinical use or on clinical trial.
ISSN:1359-7345
DOI:10.1039/b508531b