Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers

• Published in: Molecular imaging and biology Vol. 21; no. 3; pp. 509 - 518
• Main Authors: Constantinescu, Cristian C., Tresse, Cedric, Zheng, MingQiang, Gouasmat, Alexandra, Carroll, Vincent M, Mistico, Laetitia, Alagille, David, Sandiego, Christine M., Papin, Caroline, Marek, Kenneth, Seibyl, John P., Tamagnan, Gilles D., Barret, Olivier
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2019; Springer Nature B.V
• Subjects: Animal models; Animals; Biomarkers; Blocking; Brain; Brain - diagnostic imaging; Cyclotrons; Derivatives; Emission analysis; Enantiomers; Etiracetam; Fluorine; Fluorine isotopes; Fluorine Radioisotopes - chemistry; Imaging; In vivo methods and tests; Kinetics; Macaca fascicularis; Macaca mulatta; Medical imaging; Medicine; Medicine & Public Health; Nerve Tissue Proteins - metabolism; Neurodegenerative diseases; Neuroimaging; Neurological diseases; Occupancy; Positron emission; Positron emission tomography; Primates; Proteins; Radiation; Radiation dosage; Radioactive tracers; Radioisotopes; Radiology; Radiometry; Radiopharmaceuticals - chemistry; Reaction kinetics; Research Article; Substantia grisea; Synaptic density; Synaptic Vesicles - metabolism; Tissue Distribution; Tomography; MNI-126; Synaptic density; PET imaging; SV2A; F-18; Neurodegenerative disorders

Purpose Synaptic vesicle protein 2A (SV2A) serves as a biomarker of synaptic density and positron emission tomography (PET) imaging of SV2A could provide a tool to assess progression of neurodegenerative diseases. Two tracers have primarily been reported and characterized in vivo : [ 11 C]UCB-J and...