Comparative pharmacokinetics of new curcumin preparations and evidence for increased bioavailability in healthy adult participants

• Published in: International journal of clinical pharmacology and therapeutics Vol. 60; no. 12; pp. 530 - 538
• Main Authors: Hirose, Akiko, Kuwabara, Yoshitaka, Kanai, Yoko, Kato, Chieko, Makino, Yuji, Yoshi, Fukumoto, Sasaki, Kazumoto
• Format: Journal Article
• Language: English
• Published: Germany Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG 01.12.2022; Dustri-Verlag Dr. Karl Feistle
• Subjects: Adult; Area Under Curve; Bioequivalence; Biological Availability; Cross-Over Studies; Curcumin - pharmacokinetics; Humans; Pharmacokinetics; Pharmacology; Therapeutic Equivalency
• ISSN: 0946-1965
• DOI: 10.5414/CP204257

Theracurmin, which contains the curcumin composition, CR-033P, has been demonstrated to be highly bioavailable. To compare the pharmacokinetics of the three compositions, CR-033P, CR-043P using modified starch as an alternative to the dispersant gum ghatti used in the CR-033P, and TS-P1 containing the newly developed amorphous curcumin, a randomized double-blind crossover study (3-way, 3-period) was conducted. A single dose of the curcumin capsules (TS-P1 45 mg, CR-033P 90 mg, and CR-043P 90 mg) was administered to healthy adult participants. Blood sampling was performed 24 hours after capsule administration, and the plasma concentration of total curcumin was determined using high-performance liquid chromatography coupled with tandem mass spectrometry. TS-P1 and CR-043P tended to have a slightly lower area under the concentration time curve (AUC) than CR-033P, while TS-P1 displayed bioequivalence to CR-043P. Further, TS-P1 displayed bioequivalence to CR-033P in terms of AUC , while that of CR-043P tended to be lower than that of CR-033P. TS-P1 had a higher AUC than CR-043P. A statistically significant difference (p < 0.001) was found between the preparations in terms of C . TS-P1 tended to have a higher C than CR-033P, CR-043P tended to have a slightly lower C than CR-033P, and TS-P1 tended to have a higher C than CR-043P. The newly developed TS-P1 composition seemed to display similar curcumin systemic exposure except for a higher plasma concentration than the CR-033P composition. Further, only a few significant differences were found between CR-043P and CR-033P.