Comparative pharmacokinetics of new curcumin preparations and evidence for increased bioavailability in healthy adult participants
Theracurmin, which contains the curcumin composition, CR-033P, has been demonstrated to be highly bioavailable. To compare the pharmacokinetics of the three compositions, CR-033P, CR-043P using modified starch as an alternative to the dispersant gum ghatti used in the CR-033P, and TS-P1 containing t...
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Published in | International journal of clinical pharmacology and therapeutics Vol. 60; no. 12; pp. 530 - 538 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG
01.12.2022
Dustri-Verlag Dr. Karl Feistle |
Subjects | |
Online Access | Get full text |
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Summary: | Theracurmin, which contains the curcumin composition, CR-033P, has been demonstrated to be highly bioavailable. To compare the pharmacokinetics of the three compositions, CR-033P, CR-043P using modified starch as an alternative to the dispersant gum ghatti used in the CR-033P, and TS-P1 containing the newly developed amorphous curcumin, a randomized double-blind crossover study (3-way, 3-period) was conducted.
A single dose of the curcumin capsules (TS-P1 45 mg, CR-033P 90 mg, and CR-043P 90 mg) was administered to healthy adult participants. Blood sampling was performed 24 hours after capsule administration, and the plasma concentration of total curcumin was determined using high-performance liquid chromatography coupled with tandem mass spectrometry.
TS-P1 and CR-043P tended to have a slightly lower area under the concentration time curve (AUC)
than CR-033P, while TS-P1 displayed bioequivalence to CR-043P. Further, TS-P1 displayed bioequivalence to CR-033P in terms of AUC
, while that of CR-043P tended to be lower than that of CR-033P. TS-P1 had a higher AUC
than CR-043P. A statistically significant difference (p < 0.001) was found between the preparations in terms of C
. TS-P1 tended to have a higher C
than CR-033P, CR-043P tended to have a slightly lower C
than CR-033P, and TS-P1 tended to have a higher C
than CR-043P.
The newly developed TS-P1 composition seemed to display similar curcumin systemic exposure except for a higher plasma concentration than the CR-033P composition. Further, only a few significant differences were found between CR-043P and CR-033P. |
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ISSN: | 0946-1965 |
DOI: | 10.5414/CP204257 |