Environmental Triggers of Hyperuricemia and Gout

Gout is the most prevalent type of inflammatory arthritis worldwide and environmental factors contribute to hyperuricemia and risk for gout flare. Causes of hyperuricemia include increased purine consumption from meat, alcohol, and high fructose corn syrup as well as medications such as cyclosporine...

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Bibliographic Details
Published inRheumatic diseases clinics of North America Vol. 48; no. 4; p. 891
Main Authors Helget, Lindsay N, Mikuls, Ted R
Format Journal Article
LanguageEnglish
Published United States 01.11.2022
Subjects
Diuretics
Gout - therapy
Gout Suppressants - therapeutic use
Humans
Hyperuricemia - etiology
Purines
Symptom Flare Up
Hyperuricemia
Environmental exposures
Diet
Epidemiology
Gout
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Summary:Gout is the most prevalent type of inflammatory arthritis worldwide and environmental factors contribute to hyperuricemia and risk for gout flare. Causes of hyperuricemia include increased purine consumption from meat, alcohol, and high fructose corn syrup as well as medications such as cyclosporine, low-dose aspirin, or diuretics. Triggers for gout flares include increased purine consumption and medication use such as urate lowering therapy and diuretics. Environmental exposures including lead exposure, particulate matter exposure, temperature fluctuations, and physiologic stress have been found to trigger flares. In the right clinical scenario, these factors should be considered when treating gout patients.
ISSN:1558-3163
DOI:10.1016/j.rdc.2022.06.009