Future AAVenues for In Utero Gene Therapy

Fetal gene therapy using safe and effective viral vectors no longer remains a distant prospect. Recently in Nature Medicine, Massaro et al. (2018) demonstrated that prenatal intracranial injection of a viral vector results in improved neurologic function, raising the intriguing possibility that in u...

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Bibliographic Details
Published inCell stem cell Vol. 23; no. 3; pp. 320 - 321
Main Author MacKenzie, Tippi C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 06.09.2018
Subjects
Female
Fetus
Genetic Therapy
Genetic Vectors
Humans
Infant
Neurodegenerative Diseases
Pregnancy
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Summary:Fetal gene therapy using safe and effective viral vectors no longer remains a distant prospect. Recently in Nature Medicine, Massaro et al. (2018) demonstrated that prenatal intracranial injection of a viral vector results in improved neurologic function, raising the intriguing possibility that in utero gene therapy may be approaching clinical applications. Fetal gene therapy using safe and effective viral vectors no longer remains a distant prospect. Recently in Nature Medicine, Massaro et al. (2018) demonstrated that prenatal intracranial injection of a viral vector results in improved neurologic function, raising the intriguing possibility that in utero gene therapy may be approaching clinical applications.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2018.08.010