Investigation of the Size Distribution for Diffusion-Controlled Drug Release From Drug Delivery Systems of Various Geometries

• Published in: Journal of pharmaceutical sciences Vol. 108; no. 8; pp. 2690 - 2697
• Main Authors: Spiridonova, Tatiana I., Tverdokhlebov, Sergei I., Anissimov, Yuri G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2019
• Subjects: controlled drug release; diffusion; drug delivery systems; mathematical modeling; microparticles; nanoparticles; mathematical modeling; drug delivery systems; microparticles; diffusion; nanoparticles; controlled drug release
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1016/j.xphs.2019.03.036

Various drug delivery systems (DDSs) are often used in modern medicine to achieve controlled and targeted drug release. Diffusional release of drugs from DDSs is often the main mechanism, especially at early times. Generally, average dimensions of DDS are used to model the drug release, but our recent work on drug release from fibers demonstrated that taking into account diameter distribution is essential. This work systematically investigated the effect of size distribution on diffusional drug release from DDSs of various geometric forms such as membranes, fibers, and spherical particles. The investigation clearly demonstrated that the size distribution has the largest effect on the drug release profiles from spherical particles compared to other geometric forms. Published experimental data for drug release from polymer microparticles and nanoparticles were fitted, and the diffusion coefficients were determined assuming reported radius distributions. Assuming the average radius when fitting the data leads to up to 5 times underestimation of the diffusion coefficient of drug in the polymer.