Impaired cerebral vasoreactivity may cause cerebral blood volume dip following obstructive sleep apnea termination

• Published in: Sleep & breathing Vol. 16; no. 2; pp. 309 - 312
• Main Authors: Virtanen, Jaakko, Noponen, Tommi, Salmi, Tapani, Toppila, Jussi, Meriläinen, Pekka
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2012; Springer; Springer Nature B.V
• Subjects: Adult; Biological and medical sciences; Blood Volume - physiology; Carbon Dioxide - blood; Cardiovascular disease; Case Report; Cerebral Cortex - blood supply; Dentistry; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Fundamental and applied biological sciences. Psychology; Humans; Internal Medicine; Male; Medical sciences; Medicine; Medicine & Public Health; Nervous system (semeiology, syndromes); Neurology; Otorhinolaryngology; Oximetry; Pediatrics; Pneumology/Respiratory System; Polysomnography - methods; Regional Blood Flow - physiology; Respiratory therapy; Sleep apnea; Sleep Apnea, Obstructive - diagnosis; Sleep Apnea, Obstructive - physiopathology; Sleep. Vigilance; Spectroscopy, Near-Infrared; Ultrasonography, Doppler, Transcranial; Vascular diseases and vascular malformations of the nervous system; Vascular Resistance - physiology; Vasodilation - physiology; Vertebrates: nervous system and sense organs; Cerebral Blood Flow; Cerebral Blood Flow Velocity; Obstructive Sleep Apnea Patient; Cerebral Blood Volume; Obstructive Sleep Apnea; Nervous system diseases; Sleep apnea syndrome; Sleep; Blood volume; Respiratory disease; Central nervous system; Sleep disorder; Sleep wake cycle; Neurological disorder; Encephalon
• ISSN: 1520-9512; 1522-1709
• DOI: 10.1007/s11325-011-0526-9

Near-infrared spectroscopy (NIRS) is a non-invasive technique for estimating cortical concentration changes of oxy-([HbO2]), deoxy- ([HbR]), and total ([HbT]=[HbO2] +[HbR]) hemoglobin [1, 2]. Cortical [HbT] is commonly used as an indicator of cerebral blood volume (CBV) changes. Obstructive sleep apnea (OSA) is characterized by apneas (pause in breathing lasting over 10 s) or hypopneas (reduced respiratory air flow lasting over 10 s, accompanied by blood oxygen desaturation of at least 4% or EEG arousal) during sleep. The resulting oxygen and sleep deprivation can lead to severe health problems ranging from fatigue to coronary artery disease and stroke.