Comparative analysis of HBV M-antigen production in leaves of individual transgenic carrot plants

A study estimated the level of accumulation of the preS2-S viral protein (M antigen) in leaf blades of two groups of transgenic carrot plants. Data indicate the presence of the signal sequence ensuring directed transport of the preS2-S antigen into ER lumens correlated with the increase in the propo...

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Published inDoklady. Biochemistry and biophysics Vol. 425; no. 1; pp. 76 - 79
Main Authors Deineko, E. V., Zagorskaya, A. A., Pozdnyakov, S. G., Filipenko, E. A., Permyakova, N. V., Sidorchuk, Yu. V., Uvarova, E. A., Pozdnyakova, L. D., Shumny, V. K., Vlasov, V. V., Hammond, R. V., Shchelkunov, S. N.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.04.2009
Springer Nature B.V
Subjects
Antigens
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Daucus
Daucus carota - cytology
Daucus carota - genetics
Daucus carota - metabolism
Diffusion
Endoplasmic Reticulum - metabolism
Hepatitis
Hepatitis B Surface Antigens - biosynthesis
Hepatitis B Surface Antigens - genetics
Hepatitis B Surface Antigens - immunology
Hepatitis B Surface Antigens - metabolism
Hepatitis B Vaccines - biosynthesis
Hepatitis B Vaccines - metabolism
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Life Sciences
Molecular Biology
Plant biology
Plant Leaves - cytology
Plant Leaves - metabolism
Plants, Genetically Modified
Protein Precursors - biosynthesis
Protein Precursors - genetics
Protein Precursors - immunology
Protein Precursors - metabolism
Protein Transport
Proteins
Transgenic plants
Vaccines
Vaccines, Edible - biosynthesis
Vaccines, Edible - immunology
Vaccines, Edible - metabolism
Transport Signal
Transgenic Plant
Edible Vaccine
DOKLADY Biochemistry
Leaf Blade
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Summary:A study estimated the level of accumulation of the preS2-S viral protein (M antigen) in leaf blades of two groups of transgenic carrot plants. Data indicate the presence of the signal sequence ensuring directed transport of the preS2-S antigen into ER lumens correlated with the increase in the proportion of plants with a high level of accumulation of the relevant protein.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672909020057