Fluorogenic 7-azidocoumarin and 3/4-azidophthalimide derivatives as indicators of reductase activity in microorganisms

[Display omitted] A series of fluorogenic heterocyclic azides were prepared and assessed as reductase substrates across a selection of Gram-negative and Gram-positive microorganisms. The majority of these azides showed similar activity profiles to nitroreductase substrates. Microorganisms that do no...

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Published inBioorganic & medicinal chemistry letters Vol. 29; no. 16; pp. 2354 - 2357
Main Authors Chalansonnet, Valerie, Lowe, John, Orenga, Sylvain, Perry, John D., Robinson, Shaun N., Stanforth, Stephen P., Sykes, Hannah E., Truong, Thang V.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 15.08.2019
Elsevier
Subjects
Chemistry
Chemistry, Medicinal
Chemistry, Organic
Fluorogenic azides
Fluorogenic substrates
Life Sciences & Biomedicine
Microorganism detection
Nitroreductase
Pharmacology & Pharmacy
Physical Sciences
Science & Technology
Fluorogenic substrates
Fluorogenic azides
Nitroreductase
Microorganism detection
REAGENTS
H2S
SULFUR
HYDROGEN-SULFIDE
FLUORESCENT-PROBE
BENZOXAZOLE
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Summary:[Display omitted] A series of fluorogenic heterocyclic azides were prepared and assessed as reductase substrates across a selection of Gram-negative and Gram-positive microorganisms. The majority of these azides showed similar activity profiles to nitroreductase substrates. Microorganisms that do not produce hydrogen sulfide reduced the azides, indicating reductase activity was not linked to hydrogen sulfide production.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2019.06.010