The relationship between severity of calcific aortic stenosis and serum uric acid levels

• Published in: Angiology Vol. 63; no. 8; p. 603
• Main Authors: Demir, Bulent, Caglar, Ilker Murat, Ugurlucan, Murat, Ozde, Cem, Tureli, Hande Oktay, Cifci, Serkan, Vural, Alper, Karakaya, Osman
• Format: Journal Article
• Language: English
• Published: United States 01.11.2012
• Subjects: Aged; Aortic Valve - diagnostic imaging; Aortic Valve - pathology; Aortic Valve - physiopathology; Aortic Valve Stenosis - blood; Aortic Valve Stenosis - classification; Aortic Valve Stenosis - diagnostic imaging; Aortic Valve Stenosis - physiopathology; Biomarkers - blood; Blood Pressure; Calcinosis - blood; Calcinosis - classification; Calcinosis - diagnostic imaging; Calcinosis - physiopathology; Coronary Angiography; Echocardiography, Doppler; Female; Humans; Male; Middle Aged; Severity of Illness Index; Uric Acid - blood
• ISSN: 1940-1574
• DOI: 10.1177/0003319711433198

Serum uric acid (SUA) level is a marker of endothelial dysfunction and oxidative stress. Consecutive patients (n = 64) with normal coronary angiography who demonstrated calcific aortic stenosis (AS) by transthoracic echocardiography were included in the study. The patients were categorized into 3 groups: 23 mild AS (12 males), 21 moderate AS (10 males), and 20 severe AS cases (10 males). Fasting SUA level was significantly higher in the severe AS group than in the moderate and mild AS groups (severe AS, 6.3 ± 1.6; moderate AS, 4.9 ± 1.3; mild AS; 4.6 ± 1.4 mg/dL; P < .001, respectively). There was a positive correlation between SUA level and maximum as well as mean aortic gradient (r = .521, P < .001 and r = .526, P < .001, respectively). There was a negative correlation between SUA level and aortic valve area (r = -.447, P < .001). Levels of SUA were increased in calcific AS cases. In addition, there was a positive correlation between severity of calcific AS and SUA levels.