Helicobacter pylori infection, gastrin and cyclooxygenase-2 in gastric carcinogenesis

• Published in: World journal of gastroenterology : WJG Vol. 20; no. 36; pp. 12860 - 12873
• Main Author: Shao, Yun
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.09.2014
• Subjects: Animals; Anti-Bacterial Agents - therapeutic use; Anticarcinogenic Agents - therapeutic use; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Cyclooxygenase 2 - metabolism; Cyclooxygenase 2 Inhibitors - therapeutic use; Cyclooxygenase-2; DNA Methylation; Epigenesis, Genetic; Gastr; Gastrin; Gastrins - metabolism; Gene Expression Regulation, Neoplastic; Helicobacter; Helicobacter Infections - complications; Helicobacter Infections - drug therapy; Helicobacter Infections - enzymology; Helicobacter Infections - microbiology; Helicobacter pylori - drug effects; Helicobacter pylori - pathogenicity; Humans; pylori; Risk Factors; Signal Transduction; Stomach - drug effects; Stomach - enzymology; Stomach - microbiology; Stomach - pathology; Stomach Neoplasms - enzymology; Stomach Neoplasms - etiology; Stomach Neoplasms - genetics; Stomach Neoplasms - microbiology; Stomach Neoplasms - pathology; Stomach Neoplasms - prevention & control; Topic Highlight; Cyclooxygenase-2; Helicobacter pylori; Gastric cancer; Gastrin

Gastric cancer is one of the most frequent neoplasms and a main cause of death worldwide, especially in China and Japan. Numerous epidemiological, animal and experimental studies support a positive association between chronic Helicobacter pylori(H. pylori) infection and the development of gastric ca...