Helicobacter pylori infection, gastrin and cyclooxygenase-2 in gastric carcinogenesis

Gastric cancer is one of the most frequent neoplasms and a main cause of death worldwide, especially in China and Japan. Numerous epidemiological, animal and experimental studies support a positive association between chronic Helicobacter pylori(H. pylori) infection and the development of gastric ca...

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Bibliographic Details
Published inWorld journal of gastroenterology : WJG Vol. 20; no. 36; pp. 12860 - 12873
Main Author Shao, Yun
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 28.09.2014
Subjects
Animals
Anti-Bacterial Agents - therapeutic use
Anticarcinogenic Agents - therapeutic use
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Cyclooxygenase 2 - metabolism
Cyclooxygenase 2 Inhibitors - therapeutic use
Cyclooxygenase-2
DNA Methylation
Epigenesis, Genetic
Gastr
Gastrin
Gastrins - metabolism
Gene Expression Regulation, Neoplastic
Helicobacter
Helicobacter Infections - complications
Helicobacter Infections - drug therapy
Helicobacter Infections - enzymology
Helicobacter Infections - microbiology
Helicobacter pylori - drug effects
Helicobacter pylori - pathogenicity
Humans
pylori
Risk Factors
Signal Transduction
Stomach - drug effects
Stomach - enzymology
Stomach - microbiology
Stomach - pathology
Stomach Neoplasms - enzymology
Stomach Neoplasms - etiology
Stomach Neoplasms - genetics
Stomach Neoplasms - microbiology
Stomach Neoplasms - pathology
Stomach Neoplasms - prevention & control
Topic Highlight
Cyclooxygenase-2
Helicobacter pylori
Gastric cancer
Gastrin
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Summary:Gastric cancer is one of the most frequent neoplasms and a main cause of death worldwide, especially in China and Japan. Numerous epidemiological, animal and experimental studies support a positive association between chronic Helicobacter pylori(H. pylori) infection and the development of gastric cancer. However, the exact mechanism whereby H. pylori causes gastric carcinogenesis remains unclear. It has been demonstrated that expression of cyclooxygenase-2(COX-2) is elevated in gastric carcinomas and in their precursor lesions. In this review, we present the latest clinical and experimental evidence showing the role of gastrin and COX-2 in H. pylori-infected patients and their possible association with gastric cancer risk.
Bibliography:Yun Shao;Kun Sun;Wei Xu;Xiao-Lin Li;Hong Shen;Wei-Hao Sun;Department of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University;Department of Gastroenterology, Affiliated Hospitalof Nanjing University of Traditional Chinese Medicine
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Correspondence to: Wei-Hao Sun, MD, PhD, Department of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. swh@njmu.edu.cn
Telephone: +86-25-68135153  Fax: +86-25-83780170
Author contributions: Shao Y and Sun WH designed and wrote the paper; Sun K, Xu W and Li XL analyzed the literature; Shen H and Sun WH checked and revised the manuscript.
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v20.i36.12860