MHC class I allele frequencies in pigtail macaques of diverse origin

• Published in: Immunogenetics (New York) Vol. 58; no. 12; pp. 995 - 1001
• Main Authors: Pratt, Bridget F, O'Connor, David H, Lafont, Bernard A P, Mankowski, Joseph L, Fernandez, Caroline S, Triastuti, Retno, Brooks, Andrew G, Kent, Stephen J, Smith, Miranda Z
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.12.2006
• Subjects: Animal models; Animals; Gene Frequency; Genes, MHC Class I; Human immunodeficiency virus 1; Humans; Immune response; Immunology; Macaca nemestrina; Macaca nemestrina - genetics; Macaca nemestrina - immunology; Primates; Simian immunodeficiency virus; T cell receptors

Pigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS. Major Histocompatibility complex (MHC) class I-restricted CD8(+) T cell responses are a critical part of the adaptive immune response to HIV-1 in humans and simian immunodeficiency virus (SIV)...