Polyoxygenated dihydropyrano[ 2,3-c]pyrrole-4,5-dione derivatives from the marine mangrove-derived endophytic fungus Penicillium brocae MA-231 and their antimicrobial activity

A new polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivative, pyranonigrin F （1）, together with a related known compound, pyranonigrin A （2）, were isolated and identified from Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicenn...

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Published inChinese chemical letters Vol. 26; no. 5; pp. 610 - 612
Main Authors Meng, Ling-Hong, Li, Xiao-Ming, Liu, Yang, Wang, Bin-Gui
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.05.2015
Subjects
Antibacterial activity
Mangrove-derived fungus
Penicillium brocae
Pyranonigrin F
Secondary metabolites
二氢吡喃
内生真菌
抗菌活性
氧
海洋
红树林
红树植物
衍生物
Antibacterial activity
Mangrove-derived fungus
Secondary metabolites
Penicillium brocae
Pyranonigrin F
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Summary:A new polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivative, pyranonigrin F （1）, together with a related known compound, pyranonigrin A （2）, were isolated and identified from Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these metabolites were determined based on comprehensive spectral interpretation and the absolute configuration of compound 1 was established by X-ray crystallographic analysis. Compounds 1 and 2 showed potent activity against a broad spectrum of human-, aqua-, and plant-pathogens.
Bibliography:A new polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivative, pyranonigrin F （1）, together with a related known compound, pyranonigrin A （2）, were isolated and identified from Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these metabolites were determined based on comprehensive spectral interpretation and the absolute configuration of compound 1 was established by X-ray crystallographic analysis. Compounds 1 and 2 showed potent activity against a broad spectrum of human-, aqua-, and plant-pathogens.
Mangrove-derived fungus PeniciUium brocae Secondary metabolites Pyranonigrin F Antibacterial activity
11-2710/O6
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2015.01.024