Analysis of Association at Single Nucleotide Polymorphisms in the APOE Region

The discussion of the prospects of using a dense map of single nucleotide polymorphisms (SNPs) to identify disease genes with association analysis has been extensive. However, there is little empiric evidence to support this strategy. To begin to examine the practical issues surrounding this methodo...

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Published inGenomics (San Diego, Calif.) Vol. 63; no. 1; pp. 7 - 12
Main Authors Martin, Eden R., Gilbert, John R., Lai, Eric H., Riley, John, Rogala, Allison R., Slotterbeck, Brandon D., Sipe, Catherine A., Grubber, Janet M., Warren, Liling L., Conneally, P.Michael, Saunders, Ann M., Schmechel, Donald E., Purvis, Ian, Pericak-Vance, Margaret A., Roses, Allen D., Vance, Jeffery M.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 01.01.2000
Elsevier
Subjects
Age of Onset
Aged
Alzheimer Disease - genetics
APOE gene
Apolipoproteins E - genetics
Biological and medical sciences
Case-Control Studies
Classical genetics, quantitative genetics, hybrids
Female
Fundamental and applied biological sciences. Psychology
Genetic Linkage
Genetic Markers
Genetics of eukaryotes. Biological and molecular evolution
Genotype
Human
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
single nucleotide polymorphism
Genetic mapping
Chromosome F19
Human
Nervous system diseases
Analysis method
Gene
Genetic marker
Apolipoprotein E
Alzheimer disease
Central nervous system disease
Degenerative disease
Cerebral disorder
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Summary:The discussion of the prospects of using a dense map of single nucleotide polymorphisms (SNPs) to identify disease genes with association analysis has been extensive. However, there is little empiric evidence to support this strategy. To begin to examine the practical issues surrounding this methodology, we identified 10 SNPs in the region immediately surrounding the apolipoprotein E locus (APOE), an established susceptibility gene for Alzheimer disease. Our goal was to examine patterns of allelic association to begin to investigate the question of whether APOE could have been identified using SNPs. Our strongest evidence of association was at the 2 SNPs immediately flanking APOE.
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ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1999.6057